Multicenter study on the detection of disseminated tumor cells in primary node-positive breast cancer
KE Effenberger, E Borgen, C zu Eulenburg, A Grosser, K Pantel, M Synnevstedt, B Naume · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Detection of disseminated tumor cells (DTC) in bone marrow (BM) has prognostic value in primary breast cancer (BC). Anti-cytokeratin (CK) antibodies (Abs) have been established as detection markers. Here we present a direct comparison of two well-established Abs. We screened BM of 65 N+ BC patients (M0, pT1–3, pN1–3). For each patient 2*106 cells were analyzed per Ab, using A45-B/B3 (A45) and AE1/AE3 (AE) Abs in parallel. Two cell scorings were carried out and compared for both Abs independently, called “Oslo“- and “HH“-scoring. 8/65 (12.3%) were BM+ for A45, and 13/65 patients (20.0%) for AE, respectively. Conc…
