The chemokine receptor CXCR3 regulates NK and NKT cell recruitment during acute liver injury
M Moreno Zaldivar, ML Berres, P Schmitz, C Offermanns, K Karlmark, F Tacke, N Gassler, C Trautwein, HE Wasmuth · Zeitschrift für Gastroenterologie · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: Chemokines are important mediators during liver injury through modulation of immune cell recruitment. The CXCR3 ligand CXCL9 is the main chemokine for NK and NKT cell recruitment to the liver, but the role of CXCR3/CXCL9 during acute liver injury is not established. It was the aim of the current study to investigate the role of the CXCR3/CXCL9 axis during acute liver injury. Methods: Acute liver injury was induced by a single injection of CCl4 (0.7mg/kg) in CXCR3-/- mice and wild-type littermates (n=4–6). The degree of liver injury was assessed by liver histology (H&E staining), serum transaminases, and TU…
