CareLit Fachartikel

The role of E-type cyclins for hepatic fibrogenesis in mice

YA Nevzorova, N Moro, N Gassler, P Sicinski, C Trautwein, C Liedtke · Zeitschrift für Gastroenterologie · 2008 · Heft 09

Dokument
1073133
CareLit-ID
Jahr
2008
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
YA Nevzorova, N Moro, N Gassler, P Sicinski, C Trautwein, C Liedtke
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-17 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0028-1089616

Zusammenfassung

Background and Aims: It has been recently stated, that Cyclin E1 and E2 are dispensable in continuously dividing cells, but essential for cell cycle reentry of quiescent cells. The aim of this study was to investigate the role of E-type cyclins for cells proliferation during fibrogenesis. Methods: For our studies hepatocyte-specific c-myc transgenic animals (myc) containing a knockout for either cyclin E1 (E1KO) or E2 (E2KO) were generated and analyzed after 9, 20, 40 and 60 weeks for histological and molecular markers of cell cycle activity (cyclin E1, E2, BrdU incorporation), apoptosis (TUNEL) and fibrosis (co…

Schlagworte

Zeitschrift für Gastroenterologie