Antitumoral immune response by recruitment and expansion of dendritic cells in tumors infected with telomerase-dependent oncolytic viruses

Virotherapy can potentially be used to induce tumor specific immune responses and to overcome tumor-mediated tolerance mechanisms, since apoptotic tumor cells are exposed together with viral danger signals during oncolysis. However, insufficient numbers of dendritic cells (DC) present at the site of oncolysis can limit a tumor specific immune response and the resulting therapeutic benefit. We investigated MHC class I peptide specific immune responses against model antigens ovalbumin (OVA) and hemagglutinin (HA) in mouse tumor models that support efficient replication of the oncolytic adenovirus hTert-Ad. Virothe…