The ATP-binding cassette transporter ABCG2 (BCRP) V12M and Q141K variants in Hungarian patients with IBD
P Fuszek, S Fischer, PL Lakatos, L Lakatos, A Kovacs, T Molnár, I Altorjay, M Papp, Á Szilvás, P Demeter, J Papp, R Schwab, A Tordai, H Andrikovics · Zeitschrift für Gastroenterologie · 2006 · Heft 06
Bibliografische Angaben
Zusammenfassung
Aim: ABCG2 is an important member of the multidrug resistance proteins, an 'ABC half transporter', and is modulating the absorption, cellular efficacy and toxicity of several pharmacological agents. Since no data are available in IBD, our aim was to study the ABCG2 V12M and Q141K variants and response to medical therapy and/or disease phenotype in Hungarian IBD patients. Methods: 351 unrelated IBD patients (CD: 212, age 35.7±12.6 years; UC: 139, age 43.8±15.4years) and 149 healthy subjects were investigated. ABCG2 V12M and Q141K SNPs were detected by real-time PCR. Detailed clinical phenotype was determined. Res…
