Effect of intrapyloric botulinum toxin on postsurgical gastroparesis

Background: Gastroparesis is a symptomatic chronic disorder of the stomach characterized by delayed gastric emptying in the absence of mechanical obstruction. Lesion of vagal nerve occurs in 4–40% of patients undergoing laparoscopic fundoplication and after mediastinal surgery. Botulinum toxin is a potent inhibitor of neuromuscular transmission and has been used to treat achalasia. Aim of the study was to determine the effect of intrapyloric botulinum toxin on gastric emptying of patients with postsurgical gastroparesis. Methods: 6 patients (6 female, median age: 56 years, 4/6: postfundoplication and 2/6: medias…