Drug actions on the afferent and efferent fibres of the vagal nerve in the gastric mucosal protection: a molecular pharmacological approach

Background: The gastric mucosal protection is associated with the effects of drugs affecting on the afferent and/or efferent fibers of the vagal nerve. Aims: 1. To identify the dose-response curves of drugs affecting on the afferent (capsaicin, RTX) and efferent nerves (atropine, pirenzepine, cimetidin, ranitidine, famotidine, omeprazole, esomeprazole) on gastric acid secretion, chemicals-induced gastric mucosal damage in rats and in healthy human subjects; 2. To identify and to compare the ED50 values of these compounds. Materials and Methods: 1. The observations were carried out in rats and in healthy human su…