The effects of environmental detrimental agents on the function of the hepatocytes

Introduction: Previous studies indicate that monolayer hepatocyte cultures are suitable models for the study of the development of different environmental effects that cause liver disorder. A possible environmental trauma can be the extremely low dose of chlorobenzenes (ClB), which can cause the development of hepatotoxic processes. The experimental data confirm the significant differences between the ClB treated (toxic dose) and control groups. Aim: Authors want to investigate the effects of chlorobenzenes treatment on the hepatocellular activity of the rats. Methods: Male Wistar rats (150g) were used in the ex…