Deletion of protein kinase C beta does not protect against the development of albuminuria in streptozotocin-induced experimental murine diabetic nephropathy

PKC activation is a key factor in the development of diabetic microangiopathy. Deletion of the classical PKC-isoform-alpha e.g. protects against the development of albuminuria due to a diminished loss of proteoglycans whereas increased TGF-beta1 and renal hypertrophy is not prevented. We now tested the hypothesis that deletion of PKC-beta-expression, another classical PKC isoform which has been involved in diabetic microvascular complications, will lead to protection against the development of murine experimental diabetic nephropathy. We studied PKC-beta knock-out (KO) mice (n=4/5) compared to SV129 wild type (W…