CareLit Fachartikel

Gene expression and neovascularization: analysis of mouse retinae by gene microarray

J Lin, S Zeller, J Huber, N Dietrich, Y Feng, F Vom Hagen, M Ozog, Y Ivaschenko, B Brors, HP Hammes · Diabetologie und Stoffwechsel · 2006 · Heft 06

Dokument
1073226
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
J Lin, S Zeller, J Huber, N Dietrich, Y Feng, F Vom Hagen, M Ozog, Y Ivaschenko, B Brors, HP Hammes
Ausgabe
Heft 06 / 2006
Seiten
–
Erschienen: 2006-06-19 00:00:00
ISSN
1861-9002
DOI
10.1055/s-2006-943846

Zusammenfassung

Purpose: To study the gene expression pattern during retinal neovascularization in the mouse model of retinopathy of prematurity. Method: Retinal neovascularization was induced using the retinopathy of prematurity (ROP) hyperoxia/hypoxia model. Thirty-five experimental C57BL/J6 mice were exposed to 75% oxygen from postnatal day 7 to day 12. On day 12 and day 19 (6 hours after finishing high oxygen exposur) the mice were sacrificed and the retinae were removed for RNA isolation. Gene microarray and Taqman system were used for analysis of gene expression. Eyes were also analyzed by immunohistochemistry staining in…

Schlagworte

Diabetologie und Stoffwechsel