ALCAM (CD166) contributes to inflammation in the footpad model of delayed type hypersensitivity

Introduction: RAGE is a multiligand binding receptor known to play a role in late diabetic complications. However, RAGE-/– mice are only partly protected from late diabetic complications, while blockade of ligand/AGE interaction by sRAGE mediates a nearly complete protection. This implies the presence of other receptors involved in pathophysiological settings, in which RAGE-ligands are likely to contribute to the outcome. Experimental models of the adaptive immune response have identified ALCAM (CD166) as a likely candidate to bind one or more of the RAGE ligands. Aims: We studied the effects of ALCAM blockade u…