Exercise limitation in pancreatic cancer: the potential impact of changes in body composition (cachexia)
C Heinz, J Stieler, T Karhausen, U Pelzer, Y Mori, W Doehner, A Sandek, H Oettle, S Anker, M Rauchhaus · Aktuelle Ernährungsmedizin · 2006 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: In cancer, reduced exercise capacity is frequently seen, its origin is unclear. Metabolic abnormalities within the skeletal muscle, independent of left ventricular (LV) function may contribute to exercise limitation. The objective of the study was to investigate potential mechanisms for exercise limitation in patients with pancreatic cancer (PCA). Methods: We examined 25 patients with PCA (age 61+/-11 years, mean +/- SD, Karnofsky index 85+/-10%, time since diagnosis 281+/-222 days). Exercise capacity (treadmill, RQ 1.1+/-0.1 vs. 1.2+/-0.1), LV systolic and diastolic function (echo), body composition…
