Alterations of expression and function of the Na+/H+ exchanger NHE3 during early in-flammation in IL-10 knockout Mouse
T Tessema, A Cinar, B Riederer, A Bleich, A Westendorf, J Buer, M Manns, U Seidler · Zeitschrift für Gastroenterologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction: Acute flares of Crohn's disease are often accompanied by watery diarrhea, the pathophysiology of which is incompletely understood. In distal ileum and proximal colon, electroneutral salt absorption predominantes, mediated by the Na+/H+ exchanger NHE3 and the anion exchanger SLC26A3. Aim: This study was undertaken to investigate the NHE3 mRNA and protein expression, NHE3 localization and function in the terminal ileum and proximal colon of IL-10 deficient mice, which develop a proximally predominant inflamma-tion. Methods: IL-10 +/+ and -/- mice were raised under SPF conditions, then in part trans-f…
