Cytokine-induced neutrophil chemoattractant-1 (CINC-1) is released by the non-injured liver in a rat acute-phase model

Aim of the study: The source of serum CINC-1 and consequences of its synthesis for the synthesizing tissue have not been clearly elucidated under acute-phase situation. Methods: Turpentine oil (TO) was intramuscularly injected into rats, RNA and local protein levels of acute-phase cytokines and of CINC-1 were studied in the TO injected gluteal muscle, in non-injured muscle, in the liver, kidney, lung and spleen by Real time PCR, northern blot analysis and ELISA. The serum levels of acute-phase mediators and of CINC-1 were measured together with the cell numbers of the total leukocyte subpopulations. Recruitment…