An integrated clinical-genomics approach identifies a candidate multi-analyte blood test for serous ovarian carcinoma
I Meinhold-Heerlein, D Bauerschlag, K Bräutigam, J Sehouli, E Stickeler, D Könsgen, F Hilpert, C von Kaisenberg, J Pfisterer, T Bauknecht, T Schollmeyer, W Jonat, N Arnold · Geburtshilfe und Frauenheilkunde · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Purpose: Cancer of the ovary confers the worst prognosis among women with gynecological malignancies, underscoring the need to develop new biomarkers for detection of early disease, particularly those that can be readily monitored in the blood. Experimental Design: We developed an algorithm to identify secreted proteins encoded among ~22,500 genes on commercial oligonucleotide arrays, and applied it to gene expression profiles of 67 stage 1-IV serous papillary carcinomas and 9 crudely enriched normal ovarian tissues, to identify putative diagnostic markers. ELISA assays were used to validate increased levels of…
