Regulation of angiogenic factors TIMP-1, CTGF and Mac25 by chorionic gonadotropin in human granulosa lutein cells

As prerequisite for development and maintenance of many diseases angiogenesis is of particular interest in medicine. Pathologic angiogenesis takes place in chronic arthritis, collagen diseases, arteriosclerosis, retinopathy associated with diabetes, and in particularly in cancers. In the ovarian corpus luteum angiogenesis regularly occurs as a physiological and particulary a controlled process, even more intensively than in any known tumor. This angiogenesis strongly depends on ovarian cycles and sexual steroid hormones. Attempting to understand the regulatory mechanisms of angiogenesis in the human ovary we stu…