TCD-profiling. Evaluation beyond the human eye of transcranial Doppler ultrasound flow spectra in subjects with cerebral microangiopathy and controls using AVERAGE

Aims: Transcranial Doppler ultrasound (TCD) flow spectra of the larger intracranial arteries probably contain relevant information about the microcirculation as shown by increased pulsatility index (PI) or resistance index (RI) in patients with untreated severe cerebral microangiopathy (CM). However, a number of other factors influence flow spectra characteristics. We assume that using analysis of averaged flow spectra could be useful to adjust for a number of confounders. Methods: 12 subjects (aged 63±5 years) with MRI signs of severe CM, but without a history of stroke or vascular dementia and 12 age matched (…