MRI correlates of lesion pathology in T-cell clone mediated mouse experimental autoimmune encephalomyelitis
S. Nessler, S. Boretius, C. Stadelmann, A. Bittner, D. Merkler, T. Michaelis, H.P. Hartung, W. Brück, J. Frahm, N. Sommer, B. Hemmer · Aktuelle Neurologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Magnetic resonance imaging (MRI) techniques are widely used to investigate multiple sclerosis (MS) lesions. Histopathological correlates of MRI signal alterations, however, are still poorly defined. Here, we compared MRI and histopathology in a murine experimental autoimmune encephalomyelitis (EAE) model. Brainstem lesions were induced by the adoptive transfer of a PLP139–51 specific T-cell clone in SJL/J mice. 25 of 27 histopathologically identified acute EAE lesions were retrieved by T1- and T2-weighted high-resolution 3D MRI. Lesions varied with respect to signal intensity on T1- and T2-weighted images. Two d…
