CareLit Fachartikel
Analysis of antigen-presenting functionality of rat hepatic stellate cells
M Bomble, AM Gressner, R Weiskirchen · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
1074159
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Jahr
2009
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Zusammenfassung
Introduction: The classical functions of hepatic stellate cells (HSCs) are fat storage, vitamin A uptake and metabolism [1]. In response to cellular stress, HSCs transdifferentiate into myofibroblasts (MFB) and produce extracellular matrix proteins. Therefore, they have been implicated in the development if liver fibrosis and subsequent cirrhosis [2]. Recent investigations showed the antigen presentation capability of HSC [3–5]. Human and mice HSCs express genes typical for antigen- presenting cells (APC) including major histocompatibility complex (MHC) class II and the co-stimulatory molecules CD80 and CD86. Ai…
Schlagworte
IL-2
MHCII
antigen presenting cells
fibrogenesis
hepatic stellate cells
Zeitschrift für Gastroenterologie
