Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid de-differentiation and TGF-β induced apoptosis
P Godoy, JG Hengstler, I Ilkavets, C Meyer, A Bachmann, A Müller, G Tuschl, SO Müller, S Dooley · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
Hepatocytes in culture are a valuable tool to investigate mechanisms involved in the response of the liver to cytokines. However, it is well established that hepatocytes cultured on monolayers of monomeric collagen dedifferentiate, loosing specialized liver functions. Here we report that hepatocyte dedifferentiation is a reversible consequence of a specific signaling network constellation triggered by the extracellular matrix. Monomeric collagen activates focal adhesion kinase (FAK) via Src leading to activation of the Akt and ERK1/2 pathways. Akt causes resistance to TGF-β-induced apoptosis by antagonizing p38,…
