Impaired hepatocyte priming contributes to dysregulated proliferation and leads to death during liver regeneration in conditional NEMO ko mice

IKKγ/NEMO is the regulatory subunit of the IKK complex activating the transcription factor NF-κB. Hepatocyte-specific NEMO knock-out (ko) animals show a complete inhibition of NF-κB signalling in parenchymal cells leading to a severe phenotype. The animals develop spontaneous hepatocyte apoptosis counterbalanced by proliferation, progressing to hepatocellular carcinoma. As NF-κB is involved in early events of hepatocyte proliferation, we studied the impact of hepatocyte-specific NEMO deletion on liver regeneration. �70% partial hepatectomy (PH) was performed on 8 weeks old NEMOf/f (wt) and NEMOΔhepa (ko) mice to…