Regulation of nuclear receptors in non-alcoholic fatty liver disease: insights from ob/ob-mice

Introduction: Non-alcoholic fatty liver diseases (NAFLD) affects ≤25% of the general population. Several nuclear receptors (NR) have been implied in the progression of NAFLD, e.g. through the regulation of FAS by Lrh-1, LXR and FXR and induction of PPARγ which is activated by PXR and influences Srebp-1c expression. KO-mice-studies assigned FXR a protective role in fatty liver development whereas the absence of SHP ameliorates fatty liver, intriguingly. Here we investigated NR regulation in NAFLD as a prerequisite for further therapeutic strategies in the ob/ob mouse-model. Methods: 8 week-old male ob/ob-mice and…