Reperfusion injury to steatotic rat livers after transplantation can be attenuated with a modified HTK solution
Q Liu, A Nickkholgh, H Bruns, E Mohr, C Flechtenmacher, M Zorn, MW Büchler, U Rauen, P Schemmer · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Ischemia/reperfusion injury (IRI) is still an obstacle especially in fatty livers. Most recently a modified histidine-tryptophan-ketoglutarate (HTK) solution, Custodiol-N, has been developed. This solution contains N-acetyl-histidine as buffer, the amino acids aspartate, glycine, alanine, and arginine to limit ischemic injury and to improve reperfusion and the iron chelators deferoxamine and LK 614 to inhibit cold-induced cell injury. This study was designed to test the effects of Custodiol-N on IRI to fatty livers in a rat liver transplantation model. Methods: Moderate steatosis was induced by a single do…
