CareLit Fachartikel
RNAi-regulated oncolytic Adenovirus selective for p53-dysfunctional tumors
E Gürlevik, P Schache, N Strüver, MP Manns, S Kubicka, F Kühnel · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
1074171
CareLit-ID
Jahr
2009
Publikation
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Metadaten
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Zusammenfassung
Inactivation of p53-transcriptional activity is a crucial step of tumorigenesis and occurs in the majority of human cancers. Consequently, transcriptional p53-deficiency represents an excellent broad-range target for tailored therapies. We have developed the oncolytic adenovirus Ad-iREP-2 for selective replication in tumor cells without functional p53. To control its replication, Ad-iREP-2 contains an RNAi-network, that is selectively expressed in response to active p53 and then interferes with adenoviral genes essentially involved in the early onset of viral DNA-replication. Expression of the RNAi-network resul…
Schlagworte
RNAi-network
multiple shRNAs
oncolytic virus
p53
tumorselective
Zeitschrift für Gastroenterologie
