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The interferon stimulated gene 15 functions as a proviral factor for HCV and is enhanced in the liver of patients with genotype 1

R Bröring, M Trippler, G Gerken, JF Schlaak · Zeitschrift für Gastroenterologie · 2009 · Heft 01

Dokument
1074176
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
R Bröring, M Trippler, G Gerken, JF Schlaak
Ausgabe
Heft 01 / 2009
Seiten
–
Erschienen: 2009-01-20 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1191926

Zusammenfassung

Aims: The outcome of HCV standard combination therapy has previously been associated with a strong hepatic up-regulation of a subset of interferon stimulated genes (ISGs), one of them is ISG15. The aim of this study was to further elucidate the functional role of ISG15 in HCV infection. Methods: ISG15 gene expression was suppressed in human (con1) and murine (MH1) hepatoma cells harbouring the HCV con1 replicon I377/NS3–3´ using specific siRNAs. Effects on HCV replication were determined by quantitative rtPCR and Western blot analysis. In addition, ISG15 expression was analyzed in liver samples of HCV patients p…

Schlagworte

HCV Hepatitis C Virus ISG15 Interferon Interferon stimulated gene 15 Therapy subgenomic Replicon Zeitschrift für Gastroenterologie