The chemokine receptor CXCR3 mediates NK cell recruitment and limits injury after toxic liver damage
M Moreno Zaldivar, M Berres, P Schmitz, C Offermanns, KR Karlmark, F Tacke, N Gassler, C Trautwein, HE Wasmuth · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Chemokines play an important role in liver injury by modulation of immune cell recruitment to the damaged liver. NK and NKT cells are known to be important contributers to liver cell damage. Their recruitment is mediated by the CXCR3 ligands CXCL9 and CXCL10. But the role of CXCR3 has not yet been evaluated in acute liver injury. Material and Methods: Acute liver injury was induced by injection of CCl4 (0.7mg/kg) in CXCR3-/- mice, wild-type littermates and after depletion of NK-cells in wild-type mice with an anti-asialo GM1 antibody (n=4–6). The degree of liver injury was assessed by liver histology (H&E…
