CYP24A1 polymorphisms and its influence on 25(OH)D3 and 1,25(OH)2D3 serum levels in German type 1 diabetes patients

Background: The vitamin D system has been implicated in type 1 diabetes (T1D) by epidemiological and immune intervention studies as well as by polymorphisms of the vitamin D binding protein (DBP) and CYP27B1 genes. The 25(OH)D3–24-hydroxylase (CYP24), a cytochrome P450 enzyme, initiates the inactivation or catabolism of the vitamin D metabolites. Thus, CYP24 hydroxyls 1,25(OH)2D3 to the less active from 1,24,25(OH)2D3. Thus owing the important role of the vitamin D systems we investigated the rs2248137 and rs2296421 polymorphisms within the CYP24 gene candidates for type 1 diabetes susceptibility and their possi…