Identification of TEL/AML1 (ETV6/RUNX1) Target Genes in Leukemogenesis

The t(12;21)(p13;q22) translocation gives rise to the TEL/AML1 (TEL: translocation-ets-leukemia; AML1: acute-myeloid-leukemia-1) gene fusion and is the most common chromosomal abnormality yet identified in any pediatric leukemia. TEL and AML1 are frequent targets of other chromosomal translocations in human leukemias, and inactivation of either gene disrupts normal hematopoietic development. As the DNA-binding domain of AML1 is retained in the TEL/AML1 fusion, it is expected that this fusion protein binds DNA through this domain and functions in a dominant-negative fashion. Therefore, the aim of our project is t…