Transcription factor AP2alpha (TFAP2a) regulates differentiation and proliferation of neuroblastoma cells
F Pentek, J Kirfel, S Lim, A Schramm, N Friedrichs, HE Deubzer, O Witt, R Buettner, A Eggert, JH Schulte · Klinische Pädiatrie · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Neuroblastoma, the most common extracranial solid tumour of childhood, is derived from neural crest progenitor cells. The TFAP2a transcription factor regulates neural crest patterning. We sought to analyse TFAP2a expression in 97 primary neuroblastic tumors using a tissue microarray. TFAP2a was strongly expressed in poorly differentiated neuroblastomas, while TFAP2a expression was absent in tumor cells of differentiated neuroblastic tumors. High expression of TFAP2a was monitored in 4 out of 6 neuroblastoma cell lines tested. SiRNA-mediated knock-down of TFAP2a in SH-EP human neuroblastoma cells reduced prolifer…
