Improved Stratification of Standard Risk Medulloblastoma Patients by Clinical and Biological Prognostic Factors
S Rutkowski, AO von Bueren, NU Gerber, SC Clifford, DW Ellison, MA Grotzer, W Hartmann, A zur Mühlen, K O'Toole, S Nicholson, RD Kortmann, B Lannering, T Pietsch · Klinische Pädiatrie · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Event-free survival rates of standard risk medulloblastoma (MB) average 80% in current studies. We aim to improve the current risk stratification of standard MB patients based on clinical risk factors by addition of biological markers. MB patients at age between 3 and 22 years, absence of metastasis and groß total or near groß total surgical excision are considered as standard risk patients and were treated in the prospective randomised HIT-SIOP PNET4 trial by conventional or hyperfractionated radiotherapy between 2001 and 2006. Residual tumor was assessed by radio-imaging, histopathological diagnosis was confir…
