The initial ventilation mode as a risk factor for chronic lung disease in infants with congenital diaphragmatic hernia

Aims: Newborns with congenital diaphragmatic hernia (CDH) may develop chronic lung disease (CLD).High frequency oscillation (HFO) as an initial ventilation mode may reduce CLD and mortality in newborns with CDH. Objective: To determine if the initial ventilation mode is a risk factor for CLD or death in newborns with CDH. Methods: Newborns with CDH born between 2000 and 2008 at the centres of the CDH Study Group were eligible for inclusion.Data on survival, ventilation treatment, and basic patient data were collected. The endpoints were CLD,defined as oxygen dependency at day 30,and death ≤ day 30.Univariate and…