A systematic review of oral ibuprofen versus intravenous indomethacin for the treatment of PDA in preterm infants
RP Neumann, S Schulzke, C Buehrer · Zeitschrift für Geburtshilfe und Neonatologie · 2009 · Heft 04
Bibliografische Angaben
Zusammenfassung
Aims: Ibuprofen administered intravenously achieves closure rates of patent ductus arteriosus (PDA) similar to indomethacin. Oral ibuprofen may be an attractive alternative. Our objective was to systematically review randomised and quasi-randomised trials comparing oral ibuprofen with i.v. indomethacin for closure of PDA. Methods: The search methods of the Cochrane Neonatal Review Group were used. Databases included PubMed, EMBASE, CINAHL, CENTRAL, and handsearching of conference proceedings. Randomised and quasi-randomised trials of oral ibuprofen versus i.v. indomethacin for closure of PDA were eligible for in…