Linking neuron and skin: matrix metalloproteinases in amyotrophic lateral sclerosis
J Brettschneider, L Fang, D Schattauer, M Teuchert, F Huber-Abel, C Hendrich, J Dorst, M Wlaschek, K Scharffetter-Kochanek, H Tumani, A Ludolph · Aktuelle Neurologie · 2009 · Heft 10
Bibliografische Angaben
Zusammenfassung
Background: Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease that mainly affects the cortical and spinal motor neurons but may also include other organs such as the sin. Matrix metalloproteinases (MMP) have been suggested to play an important role in ALS pathology. We aimed to determine whether gelatinase MMP-2 and MMP-9 could provide a link between neuronal degeneration and skin alterations observed in ALS and whether they were related to markers of oxidative stress. Methods: We measured CSF, serum and skin tissue homogenate concentrations of MMP-2 and MMP-9 using ELISA and ma…
