Brain activation patterns during real locomotion in progressive supranuclear palsy

Objectives: Characterization of pathological changes in the supraspinal network of locomotion in patients with progressive supranuclear palsy (PSP) during real locomotion. Methods: 12 PSP patients and 16 age- and sex-matched healthy controls were included in the study. As a locomotion paradigm persons had to walk with a medium velocity in a basement floor providing uniform visual environment for 10 minutes. Then [18F]-Fluoro-desoxyglucose ([18F]-FDG) was injected intravenously while the subject continued walking for further 10 minutes. Imaging started 30 minutes after tracer injection. In all participants a seco…