Serotonin affects transcranial direct current-induced neuroplasticity in humans

Background: Modulation of the serotonergic system affects long term potentiation (LTP) as well as long term depression (LTD), the likely neurophysiological derivates of learning and memory formation, as shown in animals and slice preparations so far. However, knowledge about the impact of serotonin on neuroplasticity in humans is missing. This might be however of special importance, since many neurological patients receive serotonine reuptake inhibitors, e.g. after stroke. We aimed to explore the impact of the serotonin reuptake blocker citalopram on plasticity induced by transcranial direct current (tDCS) in hu…