Characterization of estrogen-related receptor γ deficient mice

Introduction: The family of orphan nuclear receptors comprises ligand-independent intracellular or intranuclear transcription factors involved in basic physiological functions as cell metabolism, differentiation and growth. The last orphan nuclear receptor identified was the estrogen-related receptor (ERR) γ. Its role in determining morphological and phenotypical properties was examined using knockout mice. Materials & methods: ERR-γ knock out mice were generated by insertion of a β-geo cassette in the first coding exon of the gene. Tissues from mice from embryonic stages to adulthood were histologically analyse…