Non-invasive mapping of connections of the human hippocampus using diffusion imaging

Introduction: There is only little evidence from in-vivo studies on how the human hippocampus is connected to other brain areas – most information is based on post-mortem or animal tracing studies. Here we identified and evaluated specific connections between the human hippocampus and 18 ipsi- and contralateral cortical and subcortical targets. Methods and subjects: We applied a probabilistic tractography algorithm to diffusion weighted imaging data obtained from up to now 22 healthy subjects (12 male, mean age 36.18yrs, SD 12.46yrs). Seeds were the left and right hippocampus, defined by a combination of automat…