CareLit Fachartikel
Defective lung CD8+ T cells lacking NFATc2 induced lung metastasis in NFATc2 deficient mice in a bronchoalveolar adenocarcinoma murine model
JH Maxeiner, R Karwot, K Sauer, P Scholtes, R Wiewrodt, PR Galle, HA Lehr, S Finotto · Pneumologie · 2007 · Heft 02
Dokument
1075555
CareLit-ID
Jahr
2007
Publikation
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
Lung cancer, including bronchoalveolar adenocarcinoma is the major cause of death in the USA and Europe. Although lung cancer has been unresponsive to the current immunotherapy, immune-responses to tumour were obtained by combined injection of bone marrow derived DCs and CTL inducing cytokines such as IL-7. IL-7 gene in fact was used because it has the capacity to stimulate CTL responses. The transcription factors nuclear factor of activated T cells (NFAT)s are critical in regulating early gene transcription in response to T cell receptor-mediated signals in lymphocytes. Previous studies on mice lacking NFATc2,…
Schlagworte
Adenocarcinoma
B-Lymphocytes
Cytokines
After
Tumor
Pneumologie
