CareLit Fachartikel

Immune modulating and anti-proliferative properties of STAT3 inhibitor piceatannol in hepatocellular carcinoma

S Beckebaum, J Kang, J Kang, CG Klein, CE Broelsch, G Gerken, VR Cicinnati · Zeitschrift für Gastroenterologie · 2007 · Heft 01

Dokument
1075560
CareLit-ID
Jahr
2007
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
S Beckebaum, J Kang, J Kang, CG Klein, CE Broelsch, G Gerken, VR Cicinnati
Ausgabe
Heft 01 / 2007
Seiten
–
Erschienen: 2007-01-23 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2007-967796

Zusammenfassung

Aims: Preliminary results from direct ex vivo flow cytometric analysis of peripheral blood from patients with hepatocellular carcinoma (HCC) revealed an immature phenotype and a substantial reduction of circulating dendritic cell (DC) subsets that was associated with increased IL–10 concentrations in serum and with tumor progression. It has been demonstrated that IL–10 exerts itrsquor;s biologic effect on eukaryotic cells by interacting with a specific cell surface receptor resulting in subsequent downstream engagement of the JAK-STAT signaling pathway and STAT3 activation. Moreover, constitutive STAT3 tyrosine…

Schlagworte

HCC Hepatocellular Carcinoma Immune modulation STAT3 inhibitor piceatannol Tumor Blood Chemokines Apoptosis Zeitschrift für Gastroenterologie