Schizophrenia alters specific mismatch components in MEG and EEG

The mismatch negativity (MMN) is an event-related potential reflecting automatic information processing and auditory sensory memory. This measure of early cognitive function is well documented to be impaired in schizophrenia. Different paradigms and methods (EEG and magnetoencephalography, MEG), however, are applied to measure MMN and it is unclear whether they reflect one unitary mechanism. We investigated the change of MMN and its MEG counterpart in schizophrenia for a standard oddball design (80% standards, 10% duration and 10% frequency deviants) and a new optimum design (Näätänen et al. 2003; 50% standards…