CareLit Fachartikel
Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes
J Berndt, P Kovacs, M Fasshauer, MR Schön, A Körner, M Stumvoll, M Blüher · Diabetologie und Stoffwechsel · 2007 · Heft 08
Dokument
1075887
CareLit-ID
Jahr
2007
Publikation
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DOI
ja
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Zusammenfassung
Aims/hypothesis: Increased expression and activity of the lipogenic pathways in adipose tissue may contribute to the development of obesity. As a central enzyme in lipogenesis, fatty acid synthase (FASN) was identified as a candidate gene for determining body fat. Our hypothesis is that increased FASN activity/expression links metabolic alterations of caloric excess, including hyperinsulinemia, dyslipidemia and altered adipokine profile to increased body fat mass. Methods: In paired samples of visceral and subcutaneous adipose tissue from 196 lean or obese subjects, we investigated whether FASN mRNA expression i…
Schlagworte
Obesity
Adipocytes
Creatinine
Adipokine
Association
Diabetologie und Stoffwechsel
