CareLit Fachartikel
The high expression of microRNAs in brain of BB rats may act as a central switchbox of the beta-cell destruction
P Lutze, R Baguhl, I Klöting · Diabetologie und Stoffwechsel · 2007 · Heft 08
Dokument
1075890
CareLit-ID
Jahr
2007
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aim: To prove the relevance of diabetogenic gene, Iddm4, mapped on rat chromosome 6q32, a segment of the SHR chromosome 6 (D6Rat66-D6Rat3) was introgressed into the BB/OK background termed briefly BB.6S. These congenic BB.6S rats showed a dramatic reduction of diabetes frequency compared with BB/OK (14 vs. 89%). The generation of subcogenic BB.6S rats, their phenotypic characterisation and comparative gene expression analysis narrowed this type 1 diabetes-protective region of BB.6S rats in an interval of 4 Mb on 6q32. In this segment a cluster of many snoRNAs and microRNAs is located. These sno and microRNAs are…
Schlagworte
Expression
Mirnas
Weeks
Micrornas
Brain
These
Diabetes
Non-Diabetic
Chromosome
Congenic
Mirna
Comparable
Diabetologie und Stoffwechsel
