CareLit Fachartikel
The tale of visfatin – comparative analysis of molecual and biological features of human visfatin
A Körner, A Garten, M Blüher, J Kratzsch, W Kiess · Diabetologie und Stoffwechsel · 2007 · Heft 08
Dokument
1075913
CareLit-ID
Jahr
2007
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Visfatin has been described as an adipocytokine expressed in visceral adipose tissue that exerts insulin-like effects through direct interaction with the insulin receptor. Subsequent studies raised controversy on the association of visfatin with obesity and diabetes. This may be attributed to variances in the detection systems. We evaluated visfatin preparations of various sources, their molecular features and their detection in immunoassays. Visfatin mRNA and protein was endogenously expressed in human preadipocytes and adipocytes, while secretion was seen only from mature adipocytes. Overexpression and secreti…
Schlagworte
Adipocytes
Association
Chromatography
Antibodies
COS Cells
Obesity
Diabetologie und Stoffwechsel
