Clinical features and pathogenesis of inflammatory bowel disease-associated intestinal cancer

Introduction: Patients with inflammatory bowel disease (IBD) [ulcerative colitis (UC) and Crohn's disease (CD)] are at an increased risk of developing colorectal cancer (CRC). The risk factors are the duration of the disease, extensive colitis, chronic stenosis, primary sclerosing cholangitis and a family history of CRC. The prevalence, the risk factors, the clinical features and the molecular pathogenetic alterations of IBD-associated intestinal carcinoma were examined in a cohort of patients with IBD from a well-defined East-Hungarian geographical area. Methods: 14 patients with IBD-associated intestinal cance…