The non-conjugated chenodeoxycholate stimulates the luminal Cl-/HCO3- exchanger via IP3-mediated Ca2+-signalling in guinea pig pancreatic ducts
V Venglovecz, Z Rakonczay Jr, J Maléth, L Nagy, B Ózsvári, T Takács, J Lonovics, A Varró, MA Gray, BE Argent, P Hegyi · Zeitschrift für Gastroenterologie · 2007 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: We have previously shown that luminal administration of low doses (100 l'M) of non-conjugated chenodeoxycholate (CDC) stimulates, whereas, high doses (1000l'M) of this bile acid inhibits HCO3- secretion (administered either from the luminal or basolateral side) in pancreatic ductal epithelial cells (PDEC). The aim of this study was to investigate the intracellular mechanisms by which CDC exerts its effects. Methods: Isolated guinea pig intra/interlobular pancreatic ducts were microperfused from the luminal and basolateral membranes with standard Hepes or HCO3-/CO2 solutions. The effects of CDC on intracell…
