Prevalence of anti-GAD65 in Greek population with type II diabetes mellitus

Background and aims: Autoimmune destruction of pancreatic β-cells is the main cause of insulin deficiency in type I diabetes mellitus and in a number of patients with type II diabetes. The presence of markers such as GAD65 or IA2, before the development of overt disease, can identify patients at risk. The aim of this retrospective study was to evaluate the prevalence of GAD65 in the Greek type II diabetic population. Materials and methods: We examined 1225 diabetic patients divided in two groups depending on their GAD65 reactivity. Both groups (GADAb+ and GADAb-) were further subdivided according to their BMI (l…