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Prevalence of HHV-6 in human sensory ganglia

K Hüfner, V Arbusow, S Himmelein, T Derfuss, M Strupp, T Brandt, D Theil · Aktuelle Neurologie · 2007 · Heft 09

Dokument
1076156
CareLit-ID
Jahr
2007
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
K Hüfner, V Arbusow, S Himmelein, T Derfuss, M Strupp, T Brandt, D Theil
Ausgabe
Heft 09 / 2007
Seiten
–
Erschienen: 2007-09-11 00:00:00
ISSN
0302-4350

Zusammenfassung

Introduction: Herpesviruses such as herpes simplex virus type-1 (HSV-1) and varicella zoster virus (VZV) have the ability to persist for life in human sensory ganglia. When reactivated, they may cause a wide spectrum of clinical manifestations, ranging from asymptomatic viral shedding to fatal disease. Human herpes virus 6 (HHV-6) has recently been shown to persist in the central nervous system, but its prevalence in the peripheral nervous system (PNS) has not been studied. Methods: Using nested PCR, we determined the distribution of HHV-6 and its co-localization with alpha-herpesviruses (HSV-1 and VZV) in ten h…

Schlagworte

Hhv-6 Ganglia Human Hsv-1 Sensory Infection Virus Nervous System Herpesviruses Herpes Persist Aktuelle Neurologie