Prevalence of HHV-6 in human sensory ganglia
K Hüfner, V Arbusow, S Himmelein, T Derfuss, M Strupp, T Brandt, D Theil · Aktuelle Neurologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction: Herpesviruses such as herpes simplex virus type-1 (HSV-1) and varicella zoster virus (VZV) have the ability to persist for life in human sensory ganglia. When reactivated, they may cause a wide spectrum of clinical manifestations, ranging from asymptomatic viral shedding to fatal disease. Human herpes virus 6 (HHV-6) has recently been shown to persist in the central nervous system, but its prevalence in the peripheral nervous system (PNS) has not been studied. Methods: Using nested PCR, we determined the distribution of HHV-6 and its co-localization with alpha-herpesviruses (HSV-1 and VZV) in ten h…