Therapeutic plasma exchange in multifocal motor neuropathy

Background: Although there is evidence for an important role of an aberrant humoral immune response in the pathogenesis of multifocal motor neuropathy (MMN), plasma exchange (PE) has been considered to be an ineffective treatment. The reason for this contradiction is unknown and available data about the use of PE in MMN is sparse. Therefore we retrospectively analyzed the clinical efficacy of therapeutic PE and determined reasons for treatment failure of PE in patients with MMN. Methods: Clinical characteristics, electrophysiological parameters, and anti-ganglioside antibody titers in seven patients with MMN, wh…