Klinefelter syndrome and parkinsonism

Introduction: Klinefelter's syndrome has been associated with neurologic disorders such as epilepsy, essential tremor and others, but not with parkinsonism. We describe to our best knowledge the first case of Kliniefelter syndrome and parkinsonism. Case: A 27 year old male presented with a three year history of parkinsonism of the equivalence type with rest tremor in the right hand. The patient denied the occurrence of frequent falls, urinary incontinence or orthostatic dysregulation. There was no evidence of substance abuse or antidopaminergic medication in the past. However it was known for some years that the…