Effectiveness of topiramate across age groups in elderly patients with epilepsy – results of an open-label, phase IV clinical trial

Objective: To assess effectiveness of topiramate (Topamax®, TPM) in different age groups of elderly patients (≥60) with epilepsy. Methods: In this prospective, open label, multicenter phase IV flexible dose clinical trial (TOP-GER-13), elderly patients (60–64, 65–74 and ≥75 years with epilepsy irrespective of seizure type were included and followed for a median of 12 months. Doses of TPM and concomitant AEDs could be adjusted individually. Seizure frequency and adverse events were assessed at each visit. Results: 107 patients (53% male, mean age 69±7 years) were enrolled encompassing 32 patients 60–64 years, 54…